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By Alton Meister

ISBN-10: 0470122501

ISBN-13: 9780470122501

ISBN-10: 0470643501

ISBN-13: 9780470643501

Advances in Enzymology and similar parts of Molecular Biology is a seminal sequence within the box of biochemistry, supplying researchers entry to authoritative stories of the most recent discoveries in all components of enzymology and molecular biology. those landmark volumes date again to 1941, offering an unequalled view of the historic improvement of enzymology. The sequence deals researchers the newest figuring out of enzymes, their mechanisms, reactions and evolution, roles in advanced organic technique, and their software in either the laboratory and undefined. every one quantity within the sequence gains contributions by way of major pioneers and investigators within the box from worldwide. All articles are conscientiously edited to make sure thoroughness, caliber, and clarity.

With its wide variety of issues and lengthy old pedigree, Advances in Enzymology and comparable components of Molecular Biology can be utilized not just by way of scholars and researchers in molecular biology, biochemistry, and enzymology, but in addition through any scientist attracted to the invention of an enzyme, its houses, and its applications.

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Extra info for Advances in Enzymology and Related Areas of Molecular Biology, Volume 5

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The evidence, which is entirely convincing, is based on t w o main lines of experimentation: the effect of liver poisons and liver injury on the prothrombin level in plasma; and the influence exerted by vitamin K on the formation of prothrombin. It is probable that prothrombin is present in most body fluids; but the evidence as regards its distribution in tissues is unsatisfactory, since the contamination of the examined material with blood, and therefore with traces of blood prothrombin, is extremely difficult to prevent.

8 (155). The necessity of calcium for the conversion of prothrombin to thrombin by the thromboplastic factor has given rise to many explanations. Quick (171) has sought to show that prothrombin contained calcium in its molecule. Other workers (108, 138) assign a purely catalytic function to this cation. The final decision will have to await the analyses of pure prothrombin. It is possible that experiments with radioactive calcium could contribute to a solution of this problem. A discussion of methods for the determination of the prothrombin level in blood will be found in several recent monographs (16, 173).

And McKinney, H. , Science, 88, 458 (1938). , Ann. Rev. , 12,587 (1943). Mehl, J. ,Cold Spring Harbor Symposia Quant. , 6,218 (1938). SO. , RioZ. , 60, 524 (1940). 81. Miller, G. , J . , 146,339 (1942). 82. , and Stanley, W. , 141,905 (1941). 83. , 146,331 (1942). 84. ,and Cooper, G. , 135,455(1940). 85. , and Saum, A. , 126,435 (1938). 86. Ogston, A. , Biochem. J . , 37, 78 (1943). 87. ,Biochem. , 306, 125 (1940). 88. Pirie, N. , and Green, D. , Perspectives in Biochemistry. Marmillan, New York, and Cambridge Univ.

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Advances in Enzymology and Related Areas of Molecular Biology, Volume 5 by Alton Meister


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